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 Waqas Nasir Chaudhry

  • Emory University Postdoctoral Research Associate

  • BS Hons University of the Punjab, Lahore, Pakistan

  • M Phil National University of Science and Technology, Islamabad, Pakistan

  • Ph.D. National University of Science and Technology, Islamabad, Pakistan 

I am currently working on two projects.  One, which I am doing in collaboration with Emory faculty colleagues, Nicole Vega, Marcin Grabowitz, an Emory undergraduate students, Esther Lee, a high school student, Zoe Weiss, a visiting graduate student from Chile, Rodrigo Gonzalez and Bruce Levin, is a astudy of the population and evolutionary dynamics and the conditions for the maintenance of lytic bacteriophage on mucoid populations of Escherichia coli K12 and Pseudomonas aeruginosa, PA14.     One goal of the Pseudomonas elements of this study, on which we are also collaborating with Nicole Vega and Joanna Goldberg, her Postdoc Ashley Cross, as well as Edze Westra from Essex Univeristy, GB, is to elucidate the conditions under which lytic phage will select for and maintain CRISPR-Cas immunity in populations of bacteria capable of generating resistant mutants.  My second project is with E. coli K12 and temperate and virulent mutants of the phage Lambda.  One goal of this study, which I am doing in collaboration with Nicole Vega, Adithi Govindan, Rodigo  Gonzalez and Bruce Levin is elucidate the conditions under which selection will maintain a temperate mode of phage replication, lysogeny, rather than a purely virulent mode.  Another goal is to determine the conditions under which selection will favor the carriage of host-expressed genes on the prophage of temperate viruses rather than the chromosomes of bacteria.

 

For information about these projects, write to me at waqas.mmg@gmail.com.