Amoolya Singh
| Computational & Life Sciences Fellow
B.S. Carnegie Mellon University
you can also visit my webpage
A detailed understanding of how organisms respond to environmental stress requires knowledge of not only the genetics and physiology of stress responses, but also their dynamics and mechanisms of evolution. Humans, animals, plants, and microbes live in constantly changing environments under frequently adverse conditions. To survive, they must have sophisticated stress responses. These stress responses are carried out by complex gene regulatory networks that accurately sense the stress, choose the appropriate response (whether fight, flight, or non-violent resistance), and carry it out. However, because of the changing environment, the stress responses must also retain evolvability, i.e. the ability to cope with previously-unseen circumstances. Understanding this tradeoff between complexity and evolvability is a critical aspect of the challenge before us. To progress towards this ambitious goal, I focus on characterizing the mechanisms of evolution of stress responses, primarily in bacteria (with the labs of Bruce Levin, Roberto Kolter, and Jim Fredrickson). More recently, I have been applying systems-level metaphors in order to understand the evolution of the immune system (with Rustom Antia) and the functioning of the endocrine system (with Desmond Mascarenhas). |
PublicationsReduction of albuminuria in db/db mice by the novel agents nephrilin and anephril involves overlapping but distinct biochemical mechanisms Discovering functional novelty in metagenomes: examples from light-mediated processes Modularity of stress response evolution Quantitative assessment of protein function prediction from metagenomics shotgun sequences Protein function space: viewing the limits or limited by our view? Early adoption of new drug treatments: the role of continuing medical education and physician adaptivity |
